Library / Peptides / Weight Management / 5-Amino-1MQ

Theoretical · Grade C

5-Amino-1MQ

5-Amino-1-Methylquinolinium

Evidence

Theoretical

Route

Oral

Frequency

Once daily

Mechanism.

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism. It was developed as a research tool to study NNMT's role in obesity and metabolic dysfunction. In preclinical studies, it has been shown to reduce fat mass and increase energy expenditure in diet-induced obese mice without affecting food intake.

Think of NNMT as a drain that leaks away your cell's energy currency. 5-Amino-1MQ plugs that drain, so your cells retain more fuel-burning capacity and your fat cells work harder to burn energy instead of storing it.

Mechanism · technical

5-Amino-1MQ selectively inhibits NNMT, which normally methylates nicotinamide and consumes SAM (S-adenosylmethionine) in the process. By blocking NNMT, it increases intracellular NAD+ levels and SAM availability, which upregulates sirtuin activity and enhances cellular energy expenditure. This shifts adipocyte metabolism toward a more thermogenic, energy-burning phenotype.

Part 02 · Dosing & administration

How it's taken.

Values below describe how 5-Amino-1MQ has been administered in published trials and labeling. Provided for educational purposes only — this is not medical advice and not instructions for self-administration. Consult your healthcare provider before making any health decision.

Standard dose

50-100 mg/day

Oral · Once daily

Duration

4-12 weeks typical cycle

No established human clinical protocol. Dosing based on preclinical research data — no FDA-approved human protocol exists. Research compound only.

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Part 03 · Safety

Side effects, rare serious events, who shouldn't.

Reported side effects

No human safety data exists. In animal studies, it appeared well-tolerated without significant adverse effects on food intake or behavior. Theoretical concerns include disruption of methylation balance and unknown long-term effects on NAD+ metabolism.

Absolute · do not use

Pregnancy or breastfeeding

Children under 18

Known hypersensitivity to 5-Amino-1MQ or any component

Severe hepatic impairment (metabolized via liver pathways)

Active malignancy (effects on cellular metabolism not studied in cancer)

Interactions

Metformin

Both affect cellular energy metabolism and NAD+ pathways; theoretical risk of additive metabolic effects

Moderate

NAD+ precursors (NMN, NR)

Additive increase in NAD+ levels; clinical significance unknown

Minor

NNMT-dependent medications

NNMT inhibition may alter metabolism of drugs processed through nicotinamide methylation pathways

Moderate

Labs to monitor

CMP (Comprehensive Metabolic Panel)

Baseline and every 3 months

Monitor liver and kidney function during NNMT inhibition

Fasting Lipid Panel

Baseline and every 3 months

Track lipid changes with metabolic shifts

Fasting Insulin & Glucose

Baseline and monthly

Assess insulin sensitivity changes

CBC with Differential

Baseline and every 3 months

General safety monitoring

Part 04 · Research log

Every study we cite.

Each study with its published finding and a plain-language note on limitations or funding.

2018

Selective and membrane-permeable small molecule inhibitors of NNMT reverse high fat diet-induced obesity in mice

5-Amino-1MQ reduced body weight and adipocyte size in obese mice without affecting food intake

Preclinical only; single research group

PMID 30016637 ↗

2020

NNMT as a therapeutic target for obesity

NNMT inhibition shifted adipocyte metabolism toward energy expenditure

Review article; no human trial data

Part 05 · Cost & access

Where you can get it.

Regulatory status

Not FDA-approved. Available as a research chemical. Not scheduled or controlled, but sold for research purposes only. Some compounding pharmacies have offered it off-label.

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Part 06 · Your appointment

Questions to bring.

Are there any human clinical trials for 5-Amino-1MQ that support its safety and efficacy?

How does NNMT inhibition compare to other metabolic interventions I might consider?

What are the potential risks of long-term NNMT inhibition on methylation pathways?

Is identity and purity independently verified for the supply you would dispense, and what assay methods are used?