Library / Peptides / Cognitive & Neuro / Pinealon
Theoretical · Grade C

Pinealon

Pinealon (EDR Peptide)
Evidence
Theoretical
Route
Oral or Sublingual
Frequency
Once daily
Category
Cognitive & Neuro
TL;DR
Pinealon is a synthetic tripeptide (Glu-Asp-Arg, or EDR) developed by Russian gerontologist Vladimir Khavinson as part of his bioregulatory peptide program. It is designed to mimic peptides naturally derived from the pineal gland and is proposed to have neuroprotective and geroprotective properties.
Part 01 · How it works

Mechanism.

Pinealon is a synthetic tripeptide (Glu-Asp-Arg, or EDR) developed by Russian gerontologist Vladimir Khavinson as part of his bioregulatory peptide program. It is designed to mimic peptides naturally derived from the pineal gland and is proposed to have neuroprotective and geroprotective properties. Research is primarily from Russian institutions and consists mostly of in vitro and animal studies with limited clinical data.

Pinealon is like a short text message sent to your brain cells' genetic instruction manual, nudging them to keep running their protective and repair programs. Think of it as a tiny molecular reminder to your neurons to stay in maintenance mode rather than shutting down.

Mechanism · technical
Pinealon is proposed to work through epigenetic mechanisms, penetrating cell membranes and interacting with DNA to regulate gene expression related to neuroprotection and cellular senescence. In vitro studies suggest it can modulate the expression of genes involved in apoptosis and oxidative stress in neuronal cell cultures. It has been reported to normalize melatonin production and circadian rhythm signaling. The exact molecular targets and binding partners have not been definitively characterized in peer-reviewed Western literature.
Part 02 · Dosing & administration

How it's taken.

Values below describe how Pinealon has been administered in published trials and labeling. Provided for educational purposes only — this is not medical advice and not instructions for self-administration. Consult your healthcare provider before making any health decision.

Standard dose
10-20 mg oral or 5-10 mg sublingual
Oral or Sublingual · Once daily
Duration
10-20 day cycles, repeated every 3-6 months

Khavinson tripeptide (Glu-Asp-Arg) bioregulator targeting CNS/pineal gland. Based on Russian bioregulatory peptide protocols. No FDA-approved indication. Available as supplement in some markets.

Need help with reconstitution?

Use the free peptide calculator for dilution, unit conversion, and injection volume.

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Part 03 · Safety

Side effects, rare serious events, who shouldn't.

Reported side effects
Very limited safety data. Russian studies report good tolerability with no significant adverse effects. However, these studies have not been independently replicated in Western peer-reviewed literature. The long-term safety profile is unknown.
Absolute · do not use
×
Pregnancy or breastfeeding
×
Children under 18
×
Known hypersensitivity to pinealon or any component
×
Active seizure disorders (neuropeptide effects on CNS not fully characterized)
Interactions
Sedatives and sleep aids
Pinealon influences pineal gland function and may potentiate sedative effects
Moderate
Melatonin supplements
Pinealon may enhance endogenous melatonin production; additive sleep-promoting effects
Minor
Antidepressants (SSRIs)
Pinealon modulates CNS neuropeptide signaling; theoretical interaction with serotonergic medications
Minor
Labs to monitor
CMP (Comprehensive Metabolic Panel)
Baseline and every 3 months
General metabolic safety
CBC with Differential
Baseline and every 3 months
General safety monitoring
Melatonin Level (optional)
Baseline (optional)
Pinealon targets pineal gland function
Part 04 · Research log

Every study we cite.

Each study with its published finding and a plain-language note on limitations or funding.

01
2011
0
Pinealon peptide and neuroprotection
Pinealon showed neuroprotective effects and promoted cell survival in oxidative stress models
In vitro/preclinical; Khavinson group
02
2014
0
Short peptide bioregulators in age-related CNS pathology
Pinealon improved cognitive function markers in elderly patients in a small study
Small clinical study; Khavinson group; potential conflict of interest
Part 05 · Cost & access

Where you can get it.

Regulatory status
Not FDA-approved. Available as a dietary supplement or research peptide in some markets. Registered as a pharmaceutical in Russia through Khavinson's Institute of Bioregulation and Gerontology. No regulatory approval outside of Russia.
The Peptide Column takes no affiliate commission from any source.
Part 06 · Your appointment

Questions to bring.

01
What is the quality and reproducibility of the evidence behind Pinealon?
02
How does Pinealon compare to well-established neuroprotective strategies?
03
Are there independent (non-Russian) studies validating Pinealon's proposed mechanisms?
04
What are the risks of using a peptide with limited peer-reviewed safety data?